Yap P. Chuan, Tania Rivera-Hernandez, Nani Wibowo, Natalie K. Connors, Yang Wu, Fiona K. Hughes, Linda H.L. Lua and Anton P.J. Middelberg Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine Biotechnology and Bioengineering 110
Modularization of a peptide antigen for presentation on a microbially-synthesized murine polyomavirus (MuPyV) virus-like particle (VLP) offers new alternatives for rapid and low-cost vaccine delivery at a global scale. Immunization with a modular MuPyV VLP presenting an antigenic element from group A streptococcus (GAS) induced high levels of antibodies against the element despite a strong pre-existing anti-carrier immune response. This study also demonstrated the possibility of modularizing the VLP to present up to 720 copies of the antigenic element.
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