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Charles H. Tegeler, Sandhya R. Kumar, Dave Conklin, Sung W. Lee, Lee Gerdes, Dana P. Turner, Catherine L. Tegeler, Brian C. Fidali and Tim T. Houle Open label, randomized, crossover pilot trial of high-resolution, relational, resonance-based, electroencephalic mirroring to relieve insomnia Brain and Behavior 2

Version of Record online: 28 OCT 2012 | DOI: 10.1002/brb3.101

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This was a randomized, unblinded, wait-list, cross over study of HIRREM plus usual care (HUC) versus usual care alone (UC), for subjects with insomnia, with a primary outcome of pre- to post-HIRREM Insomnia Severity Index (ISI) scores. Results for differential change in ISI: −10.3 (95% CI: −13.7 to −6.9), P < 0.0001, with standardized effect size of 2.68, and effects also persisted for > 4 weeks after completion of the HIRREM intervention.

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