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Caty Casas, Mireia Herrando-Grabulosa, Raquel Manzano, Renzo Mancuso, Rosario Osta and Xavier Navarro Early presymptomatic cholinergic dysfunction in a murine model of amyotrophic lateral sclerosis Brain and Behavior 3

Version of Record online: 17 FEB 2013 | DOI: 10.1002/brb3.104

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In the SOD1G93A ALS mouse model, an early reduction in ChAT mRNA and protein content was observed within motoneurons (MNs) somata and cholinergic synaptic boutons apposed onto lumbar spinal MNs at very early presymptomatic stage, by 30 days of life, time before the characteristic denervation occurs. Concurrent events by that time are the presence of mild oxidative stress and an increase in Tdp-43 nuclear accumulation within MNs which is involved in ChAT transcript processing.

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