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Mohammed Emamussalehin Choudhury, Kana Sugimoto, Madoka Kubo, Masahiro Nagai, Masahiro Nomoto, Hisaaki Takahashi, Hajime Yano and Junya Tanaka A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats Brain and Behavior 1

Version of Record online: 9 AUG 2011 | DOI: 10.1002/brb3.11

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Dopamine (DA) agonists are widely used as primary treatments for Parkinson's disease. However, they do not prevent progressive degeneration of dopaminergic neurons, the central pathology of the disease. In this study, we found that subcutaneous injection of a cytokine mixture containing granulocyte macrophage colony-stimulating factor and interleukin-3 (IL-3) markedly suppressed dopaminergic neurodegeneration in 6-hydroxydopamine-lesioned rats, an animal model of Parkinson's disease.

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