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Luca Passamonti, Maria Salsone, Nicola Toschi, Antonio Cerasa, Marco Giannelli, Carmelina Chiriaco, Giuseppe Lucio Cascini, Francesco Fera and Aldo Quattrone Dopamine-transporter levels drive striatal responses to apomorphine in Parkinson's disease Brain and Behavior 3

Version of Record online: 22 MAR 2013 | DOI: 10.1002/brb3.115

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We studied how dopamine-transporter (DAT) levels influenced brain responses to apomorphine, a potent dopamine agonist, in Parkinson's disease (PD) patients executing a working-memory task. We found an inverted-U-shaped relation between DAT levels and striatal response to apomorphine and interpreted these findings as reflecting changes in striatal D2-receptor sensitivity. In future, multimodal brain markers may be useful for personalizing drug therapy in PD.

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