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João P. Lopes, Glauco Tarozzo, Angelo Reggiani, Daniele Piomelli and Andrea Cavalli Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity Brain and Behavior 3

Article first published online: 11 JAN 2013 | DOI: 10.1002/brb3.118

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We investigated the neuroprotective effects of galantamine and memantine, alone and in combination, on rat primary cortical neurons against an NMDA excitotoxic challenge. Combinations of individually nonactive concentrations of the two drugs afford full neuroprotection, through pathways involving NR2B-containing NMDA receptors and nicotinic receptors.

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