C. Jean Loria, Ashley M. Stevens, Ellen Crummy, Gemma Casadesus, Frank J. Jacono, Thomas E. Dick and Ruth E. Siegel Respiratory and behavioral dysfunction following loss of the GABAA receptor α4 subunit Brain and Behavior 3
Knockout of the GABAA receptor α4 subunit in mice led to changes in the breathing pattern (reduced variability) and increased anxiety-like behavior. α4 subunit loss also resulted in reduced expression of other extrasynaptic (α6 and δ) subunit mRNAs in the pons without changes in the most prominent synaptic subunits. These findings suggest that the regulation of extrasynaptic GABAA receptor subunits in the pons influences respiratory control and adaptation to stress.
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