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Yaso Emmanuel, Lowri E. Cochlin, Damian J. Tyler, Celeste A. de Jager, A. David Smith and Kieran Clarke Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance Brain and Behavior 3

Version of Record online: 15 FEB 2013 | DOI: 10.1002/brb3.124

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The physiological role of insulin in brain glucose uptake has not previously been well characterized. We propose that the kinetics of insulin mediated glucose uptake are such that in the brain, it may play a role in facilitating the required acute rapid increases in neuronal glucose uptake in response to cognitive activity. We present data from a new in vivo experimental in vivo approach which supports this proposed role.

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