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Leonardo Pignataro, Florence P. Varodayan, Lindsay E. Tannenholz, Petr Protiva and Neil L. Harrison Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway Brain and Behavior 3

Version of Record online: 6 FEB 2013 | DOI: 10.1002/brb3.125

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The presence of ethanol alters the redox state of astrocytes, triggering an increase in expression of genes related to oxidoreductases, antioxidants, stress, and apoptosis. We also observed the regulation of genes that control the immune response, as well as those involved in acetyl-CoA and lipid metabolism. The data presented in this work suggest that a significant subset of the astrocyte alcohol-sensitive genes are regulated by HSF1, perhaps via the genetic alcohol-responsive element (ARE).

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