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Xuezhi Cui, Ying-Qi Weng, Isabelle Frappé, Alison Burgess, M. Teresa Girão da Cruz, Melitta Schachner and Isabelle Aubert The cell adhesion molecule L1 regulates the expression of choline acetyltransferase and the development of septal cholinergic neurons Brain and Behavior 1

Article first published online: 31 JUL 2012 | DOI: 10.1002/brb3.15

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Mutations in the L1 gene cause severe brain malformations and mental retardation. We investigated the potential roles of L1 in the regulation of choline acetyltransferase (ChAT) and in the development of septal cholinergic neurons, which are known to project to the hippocampus and play key roles in cognitive functions.

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