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Yi Pang, Lir-Wan Fan, Lu-Tai Tien, XueMei Dai, Baoying Zheng, Zhengwei Cai, Rick C. S. Lin and Abhay Bhatt Differential roles of astrocyte and microglia in supporting oligodendrocyte development and myelination in vitro Brain and Behavior 3

Version of Record online: 9 JUL 2013 | DOI: 10.1002/brb3.152

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The current study examined the effects of microglia and astrocyte-conditioned medium on oligodendrocyte (OL) developmental phenotypes including cell survival, proliferation, differentiation and myelination in vitro. Our data reveal that although both astrocytes- and microglia-conditioned medium (ACDM and MCDM) protect OL progenitor cells (OPCs) against growth factor withdrawal-induced acute cell death, they differentially affect OL proliferation, differentiation, long-term survival, and myelination. The differential effects of astrocytes and microglia on OL development is highlighted by distinct patterns of cytokine in the conditioned medium, as well as intracellular signaling pathways activated in OLs upon exposure to the conditioned medium.

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