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Seema Yousuf, Fahim Atif, Varun Kesherwani and Sandeep Kumar Agrawal Neuroprotective effects of Tacrolimus (FK-506) and Cyclosporin (CsA) in oxidative injury Brain and Behavior 1

Version of Record online: 31 JUL 2012 | DOI: 10.1002/brb3.16

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The detrimental effects of hypoxic damage to central nervous system lead to energy depletion, free radical formation, lipid peroxidation (LPO), and increased calcium. We hypothesized that in vitro tacrolimus (FK-506) and cyclosporine A (CsA) could be protective against hypoxic damage in spinal cord. Dorsal columns were isolated from the spinal cord of adult rats and injured by exposure to hypoxic condition for 1 h, and treated with FK-506 (0.1 μM) and CsA (0.1 μM). After injury, reperfusion was carried out for 2 h. Tissues were collected, processed for biochemical assays, and 2,3,5-triphenyltetrazolium chloride (TTC) staining.

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