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Emilie Zanin, Jean-Philippe Ranjeva, Sylviane Confort-Gouny, Maxime Guye, Daniele Denis, Patrick J. Cozzone and Nadine Girard White matter maturation of normal human fetal brain. An in vivo diffusion tensor tractography study Brain and Behavior 1

Article first published online: 31 JUL 2012 | DOI: 10.1002/brb3.17

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We demonstrate for the first time the ability to determine in vivo and in utero the transitions between the main stages of white matter (WM) maturation in normal human fetuses using magnetic resonance diffusion tensor imaging (DTI) tractography. Biophysical characteristics of water motion are used as an indirect probe to evaluate progression of the tissue matrix organization in cortico-spinal tracts (CSTs), optic radiations (OR), and corpus callosum (CC) in 17 normal human fetuses explored between 23 and 38 weeks of gestation (GW) and selected strictly on minimal motion artifacts.

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