Nicolas Cherbuin, Perminder S. Sachdev and Kaarin J. Anstey Mixed handedness is associated with greater age-related decline in volumes of the hippocampus and amygdala: the PATH through life study Brain and Behavior 1
Handedness has been found to be associated with structural and functional cerebral differences. Left handedness and mixed handedness also appear to be associated with an elevated risk of some developmental and immunological disorders that may contribute to pathological processes developing in aging. Inconsistent reports show that left handedness may be more prevalent in early-onset as well as late-onset Alzheimer's disease, but might also be associated with slower decline. Such inconsistencies may be due to handedness being usually modeled as a binary construct while substantial evidence suggests it to be a continuous trait. The aim of this study was to investigate the relationship between brain structures known to be implicated in pathological aging and strength and direction of handedness.
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