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Elodie Deschatrettes, Peggy Jouvert and Jean Zwiller Overexpression of cyclic GMP-dependent protein kinase reduces MeCP2 and HDAC2 expression Brain and Behavior 2

Version of Record online: 17 SEP 2012 | DOI: 10.1002/brb3.92

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The present report shows that activation of cGMP-dependent protein kinase by local application of 8-bromo-cGMP in the caudate–putamen reduced the expression of the epigenetic markers, methyl-CpG-binding protein 2 (MeCP2) and histone deacetylase 2 (HDAC2) , in dopaminergic projection areas. We also studied the effect of PKG overexpression by injecting a plasmid vector containing the human PKG-Iα cDNA in either the ventral tegmental area or the caudate–putamen. Data suggest that the cGMP pathway affects cognitive processes through a mechanism that comprises the MeCP2/HDAC2 complex and the subsequent control of gene silencing.

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