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Floor E. A. Verhoeven, Linda Booij, Anne-Wil Kruijt, Hilâl Cerit, Niki Antypa and Willem Van der Does The effects of MAOA genotype, childhood trauma, and sex on trait and state-dependent aggression Brain and Behavior 2

Version of Record online: 5 OCT 2012 | DOI: 10.1002/brb3.96

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This study shows that women with the high-expression variant of the MAOA gene report more aggressive thoughts and behaviors in relation to sad mood compared with women with the low-expression variant. This effect is not observed in men, nor were there any gene by environment interactions. A protective effect of the lower expression variant in women is consistent with previous observations in adolescent girls, and suggests that the higher MAOA expression variant may predispose to aggression-related problems during depressive episodes.

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