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Victor W. Sung, Michael J. Lyerly, Kenneth B. Fallon and Khurram Bashir Isolated CNS Whipple disease with normal brain MRI and false-positive CSF 14-3-3 protein: a case report and review of the literature Brain and Behavior 2

Version of Record online: 1 OCT 2012 | DOI: 10.1002/brb3.97

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Isolated CNS WD, while rare, is important to recognize as it may be treatable and when missed can be fatal. We review the literature regarding isolated CNS WD and use our case to illustrate that the suspicion for isolated CNS WD should remain high even in the absence of commonly described features such as abnormal hyperintense lesions on MRI. Our case also had a false-positive CSF 14-3-3 protein, and therefore, isolated CNS WD should be considered in those cases as well.

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