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Anne Tsao, Edwin Pun Hui, Rosalyn Juergens, Shanthi Marur, Tan Eng Huat, Goh Boon Cher, Ruey-Long Hong, Waun Ki Hong and Anthony Tak-Cheung Chan Phase II study of TAS-106 in patients with platinum-failure recurrent or metastatic head and neck cancer and nasopharyngeal cancer Cancer Medicine 2

Article first published online: 18 APR 2013 | DOI: 10.1002/cam4.79

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TAS-106 was reasonably tolerated in patients with platinum-failure HNSCC and NPC with the 24-h continuous infusion administration schedule; however, there was no anti-tumor efficacy seen with TAS-106 monotherapy. Future studies will focus on TAS-106 combinations and mechanisms of drug resistance.

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