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Michael Groll, Matthias Bochtler, Hans Brandstetter, Tim Clausen and Robert Huber Molecular Machines for Protein Degradation ChemBioChem 6

Version of Record online: 28 JAN 2005 | DOI: 10.1002/cbic.200400313

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How to have a break down. One of the most precisely regulated processes in living cells is intracellular protein degradation. Here, the current state of knowledge about protein-degradation systems is summarised, with the focus on the proteasome (see structure), HslVU, Tricorn protease and its interacting factors and DegP. The structural information about these protein complexes allows the mode of action of natural and synthetic inhibitors to be studied. Some of these compounds may find therapeutic applications in contemporary medicine.

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