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Henk M. Keizer, Brian R. Dorvel, Martin Andersson, Daniel Fine, Rebecca B. Price, Joanna R. Long, Ananth Dodabalapur, Ingo Köper, Wolfgang Knoll, Peter A. V. Anderson and Randolph S. Duran Functional Ion Channels in Tethered Bilayer Membranes—Implications for Biosensors ChemBioChem 8

Version of Record online: 21 JUN 2007 | DOI: 10.1002/cbic.200700094

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The ties that bind. A biosensor based on modulation of single ion-channel activity, with the ability to detect analytes in the micromolar range was devised. Ion channels were interfaced to a gold surface and reconstituted into tethered bilayer lipid membranes (tBLMs; see scheme). Using this method we obtained single channel activities from the synthetic ion channel, M2δ, and the Ca2+-activated K+ ion channel.

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