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Manfred T. Reetz, Martin Rentzsch, Andreas Pletsch, Andreas Taglieber, Frank Hollmann, Régis J. G. Mondière, Norbert Dickmann, Birte Höcker, Simona Cerrone, Michaela C. Haeger and Reinhard Sterner A Robust Protein Host for Anchoring Chelating Ligands and Organocatalysts ChemBioChem 9

Article first published online: 13 FEB 2008 | DOI: 10.1002/cbic.200700413

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Robust hybrid catalysts: A platform for directed evolution of hybrid catalysts has been optimized and miniaturized by using a thermostable enzyme, tHisF (see figure) from Thermotoga maritima. A tHisF mutant with a strategically placed cysteine was identified and subjected to bioconjugation by introducing a variety of ligands for metal ligation, a ligand/metal moiety, and several organocatalysts such as flavin and thiazolium entities.

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