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Vu Hong, Andrew K. Udit, Richard A. Evans and M. G. Finn Electrochemically Protected Copper(I)-Catalyzed Azide–Alkyne Cycloaddition ChemBioChem 9

Article first published online: 26 MAY 2008 | DOI: 10.1002/cbic.200700768

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Convenient regeneration: The title “click” reaction is enabled by the presence of a reducing electrochemical potential and accelerating Cu-binding ligands to provide a convenient method for synthetic and bioconjugation ligations by using a highly active, but air-sensitive, catalyst.

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