Madhvi Gupta, Rudresh Acharya, Aseem Mishra, Suryanarayanarao Ramakumar, Faizan Ahmed and Virander Singh Chauhan Dehydrophenylalanine (ΔPhe) as a β Breaker: Extended Structure Terminated by a ΔPhe-Induced Turn in the Pentapeptide Boc-Phe1-Ala2-Ile3-ΔPhe4-Ala5-OMe ChemBioChem 9
Breaking the sheets: Crystallography studies illustrated the potential of α,β-dehydrophenylalanine (ΔPhe) to interrupt the propagation of an extended structure in the de novo designed pentapeptide 1. To further explore the role of ΔPhe as a β-breaker residue, it was incorporated into the 16–20 segment of the Aβ1–40 sequence. TEM studies suggest that ΔPhe might be useful as a β breaker in peptide-based antifibrillizing drugs.
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