Anne-Sophie Rebstock, Cristina Visintin, Elisabetta Leo, Cristina Garcia Posada, Sarah R. Kingsbury, Gareth H. Williams, Kai Stoeber and David L. Selwood Modular Assembly Using Sequential Palladium Coupling Gives Easy Access to the SMoC Class of Cellular Transporters ChemBioChem 9
Have a lift: The transducing ability of the third helix of transcription factor homeodomains is effectively mimicked by a biphenyl system displaying guanidine groups (see scheme). The biphenyl class of small-molecule carriers (SMoCs) can carry biomolecules into a wide variety of cell types. A “combinatorial” approach to the synthesis of SMoCs is described using sequential Pd0 coupling chemistry to assemble the molecules from highly functionalized building blocks.
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