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Deanna L. Mendez, Dr. Daesung Kim, Dr. Maksymilian Chruszcz, Dr. Gena E. Stephens, Prof. Wladek Minor, Prof. Sepideh Khorasanizadeh and Prof. Sarah C. R. Elgin The HP1a Disordered C Terminus and Chromo Shadow Domain Cooperate to Select Target Peptide Partners ChemBioChem 12

Version of Record online: 5 APR 2011 | DOI: 10.1002/cbic.201000598

Thumbnail image of graphical abstract

Shadow play: Heterochromatin protein 1a (HP1a) homodimerizes via its chromo shadow domain (CSD; black curve). HP2 is a non-histone chromosomal protein that binds to HP1a CSD dimers with two orders of magnitude tighter affinity (red curve) than the piRNA-interacting protein PIWI (blue curve). Such HP2 affinity can drive the dimerization of the HP1a CSD.

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