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Ellen Zandvoort, Bert-Jan Baas, Prof. Dr. Wim J. Quax and Dr. Gerrit J. Poelarends Systematic Screening for Catalytic Promiscuity in 4-Oxalocrotonate Tautomerase: Enamine Formation and Aldolase Activity ChemBioChem 12

Version of Record online: 3 FEB 2011 | DOI: 10.1002/cbic.201000633

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Prozymes: A systematic screening strategy to discover new promiscuous carbonyl-transformation activities in 4oxalocrotonate tautomerase (4-OT) is reported. The N-terminal proline of this enzyme provides a chemical functionality in the active site that might be suitable for enamine catalysis. It is shown that the aldol condensation of acetaldehyde with benzaldehyde is catalyzed by 4-OT.

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