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Dr. Nora Graf, Dr. Wee Han Ang, Dr. Guangyu Zhu, MyatNoeZin Myint and Prof. Stephen J. Lippard Role of Endonucleases XPF and XPG in Nucleotide Excision Repair of Platinated DNA and Cisplatin/Oxaliplatin Cytotoxicity ChemBioChem 12

Version of Record online: 30 MAR 2011 | DOI: 10.1002/cbic.201000724

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Knockdown of endonucleases: One of the mechanisms associated with platinum-based drug resistance is the enhanced excision repair activity on platinum-damaged DNA. Inhibiting endonuclease activity by the repair complex by using RNAi knockdown (see figure) impacted transcription efficiency through platinum–DNA lesions and cellular sensitivity to platinum anticancer agents.

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