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Cody J. Craig, Dr. Jessica L. Goodman and Prof. Alanna Schepartz Enhancing β3-Peptide Bundle Stability by Design ChemBioChem 12

Version of Record online: 31 MAR 2011 | DOI: 10.1002/cbic.201000753

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Building β3-peptide bundles from the “bottom-up”: The high-resolution structure of the octameric β-peptide helical bundle Zwit-1F revealed the unique core packing and surface interactions that drive β-bundle assembly. Mutating residues at the surface and optimizing salt bridges can lead to dramatic increases in assembly and thermodynamic stability.

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