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Björn Boll, Susanne Hennig, Dr. Chunsong Xie, Prof. Jae Kyong Sohng and Prof. Lutz Heide Adenylate-Forming Enzymes of Rubradirin Biosynthesis: RubC1 Is a Bifunctional Enzyme with Aminocoumarin Acyl Ligase and Tyrosine-Activating Domains ChemBioChem 12

Version of Record online: 29 MAR 2011 | DOI: 10.1002/cbic.201000778

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The rubradirin biosynthetic gene cluster encodes three putative acyladenylate-forming enzymes of aminocoumarin biosynthesis and linkage. One of these, RubC1, was shown to be a unique bifunctional enzyme, catalyzing both L-tyrosine activation and acylation of the aminocoumarin moiety. Another, Orf4, is a monofunctional aminocoumarin-acylating enzyme. The inactive RubF6 was mutated to an active acylating enzyme.

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