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Dr. Montserrat Terrazas, Dr. Sandra M. Ocampo, Dr. José Carlos Perales, Prof. Dr. Victor E. Marquez and Dr. Ramon Eritja Effect of North Bicyclo[3.1.0]hexane 2′-Deoxy-pseudosugars on RNA Interference: A Novel Class of siRNA Modification ChemBioChem 12

Version of Record online: 30 MAR 2011 | DOI: 10.1002/cbic.201000791

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Pseudonucleosides activate gene silencing too: Replacement of natural ribose rings in siRNAs by North-locked bicyclo[3.1.0]hexane 2′-deoxy-pseudosugars is accepted by the RNAi machinery and can be used to target therapeutically relevant genes. Moreover, this modification increases the serum stabilities of siRNAs and decreases immunostimulation.

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