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Dr. Olivia Vergnolle, Dr. Frank Hahn, Dr. Abel Baerga-Ortiz, Prof. Dr. Peter F. Leadlay and Dr. Jennifer N. Andexer Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase: Implications for cis Double Bond Formation ChemBioChem 12

Version of Record online: 5 APR 2011 | DOI: 10.1002/cbic.201100011

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Not a matter of preference: The polyketide borrelidin contains both a trans and a cis double bond. The corresponding dehydratases in the polyketide synthase are found to have identical preferences for thioester substrates in vitro and to generate trans double bonds, undermining the idea that cis double bonds arise from dehydration of 3S rather than 3R alcohols.

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