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Herre Jelger Risselada, Carsten Kutzner and Prof. Helmut Grubmüller Caught in the Act: Visualization of SNARE-Mediated Fusion Events in Molecular Detail ChemBioChem 12

Version of Record online: 23 MAR 2011 | DOI: 10.1002/cbic.201100020

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Cooperative and synchronized: We have simulated neuronal SNARE-mediated membrane fusion in molecular detail. At least one single SNARE complex is required for fusion, and multiple SNARE complexes mediate membrane fusion in a cooperative and synchronized process. After fusion, the zipping of the SNAREs extends into the membrane region.

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