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Dr. Jens Tilsner and Dr. Cristina Flors FIT for Purpose: PNA-Based Probes Enable mRNA Imaging in Living Cells ChemBioChem 12

Version of Record online: 4 APR 2011 | DOI: 10.1002/cbic.201100139

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If the dye FITs: A new approach for imaging mRNA in vivo is based on forced intercalation (FIT) of a dye that substitutes a base of a peptide nucleic acid hybridisation probe. Upon hybridisation with complementary mRNA, the fluorescence of the dye is greatly enhanced, improving the signal-to-noise ratio for fluorescence microscopy in living cells.

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