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Maxim Kogan, Prof. Bengt Nordén, Prof. Per Lincoln and Dr. Pär Nordell Transition State of Rare Event Base Pair Opening Probed by Threading into Looped DNA ChemBioChem 12

Version of Record online: 7 JUL 2011 | DOI: 10.1002/cbic.201100182

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Thread with care: The threading of a dumb-bell shaped ruthenium complex between two DNA strands (see figure) is dependent on rare, spontaneous duplex openings. We have investigated DNA constructs structurally mimicking hypothetical transition states, in which threading, and unthreading, proved to be greatly facilitated.

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