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Alexander G. Albrecht, Hannes Landmann, David Nette, Dr. Olaf Burghaus, Dr. Florian Peuckert, Prof. Dr. Andreas Seubert, Dr. Marcus Miethke and Prof. Dr. Mohamed A. Marahiel The Frataxin Homologue Fra Plays a Key Role in Intracellular Iron Channeling in Bacillus subtilis ChemBioChem 12

Article first published online: 8 JUL 2011 | DOI: 10.1002/cbic.201100190

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The iron trade:Bacillus subtilis frataxin (Fra) is an important iron channeling protein. After identification by a native metalloproteomics approach, we report the influence of Fra on the iron homeostasis of B. subtilis, in vivo, and show further the in vitro transfer of iron from Fra to the SUF Fe–S cluster biosynthesis component, SufU, and the final cluster transfer to aconitase, CitB (see scheme).

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