Dr. Erinna F. Lee, Assoc. Prof. Brian J. Smith, Dr. W. Seth Horne, Kelsey N. Mayer, Marco Evangelista, Prof. Peter M. Colman, Prof. Samuel H. Gellman and Dr. W. Douglas Fairlie Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design ChemBioChem 12
Killer mimetic structure: We report a crystal structure of anti-apoptotic protein Bcl-xL bound to a BH3-mimetic oligomer composed of α- and β-amino acid residues, and complementary biochemical data. The structure reveals how an α/β-peptide, developed by using a sequence-based design, can accurately mimic an α-helical prototype (see figure).
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