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Romana Spitzer, Dr. Karin Kloiber, Dr. Martin Tollinger and Dr. Christoph Kreutz Kinetics of DNA Refolding from Longitudinal Exchange NMR Spectroscopy ChemBioChem 12

Article first published online: 7 JUL 2011 | DOI: 10.1002/cbic.201100318

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Switching of DNA: We address the conformational heterogeneity of DNA on the secondary structure level. While it has been demonstrated that RNA is able to modulate function by changing its folding state, we show for the first time that DNA too can undergo transitions between energetically similar folding states on a time scale that is relevant for biological processes (see figure).

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