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Jiayin Bao, Dr. Svetlana M. Krylova, Prof. Derek J. Wilson, Oren Reinstein, Prof. Dr. Philip E. Johnson and Prof. Dr. Sergey N. Krylov Kinetic Capillary Electrophoresis with Mass-Spectrometry Detection (KCE-MS) Facilitates Label-Free Solution-Based Kinetic Analysis of Protein–Small Molecule Binding ChemBioChem 12

Version of Record online: 19 OCT 2011 | DOI: 10.1002/cbic.201100617

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Tandem tracker: Here we introduce a method for studying the kinetics of protein–small-molecule interactions based on kinetic capillary electrophoresis (KCE) separation and MS detection. Due to the variety of KCE methods and MS modes available, the KCE-MS tandem is a highly versatile platform for label-free, solution-based kinetic studies of affinity interactions.

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