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Sophie Willnow, Michael Martin, Prof. Dr. Bernhard Lüscher and Prof. Dr. Elmar Weinhold A Selenium-Based Click AdoMet Analogue for Versatile Substrate Labeling with Wild-Type Protein Methyltransferases ChemBioChem 13

Version of Record online: 30 APR 2012 | DOI: 10.1002/cbic.201100781

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Element editing: S-Adenosyl-L-methionine-dependent methyltransferases can transfer extended chemical groups (such as the propargyl group, which combines smallness, activation, and the potential for labeling after transfer) from cofactor analogues containing unsaturated bonds next to the reactive carbon. Replacing the sulfur in an unstable propargylic analogue with selenium gave a cofactor suitable for efficient protein labeling.

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