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Ana Torkar, Dr. Sarah Bregant, Dr. Laurent Devel, Dr. Marko Novinec, Dr. Brigita Lenarčič, Dr. Tamara Lah and Dr. Vincent Dive A Novel Photoaffinity-Based Probe for Selective Detection of Cathepsin L Active Form ChemBioChem 13

Article first published online: 4 NOV 2012 | DOI: 10.1002/cbic.201200389

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CatL catcher: A photoaffinity probe incorporating a photoactivatable benzophenone group was shown to label the active form of cathepsin L selectively in the presence of a set of recombinant cathepsins and cell-extracted proteins. This probe should be of value for detecting the secreted active form of cathepsin L from in vitro or ex vivo samples.

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