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Dr. Kelly D. Daughtry, Dr. Langdon J. Martin, Ashish Sarraju, Prof. Barbara Imperiali and Prof. Karen N. Allen Tailoring Encodable Lanthanide-Binding Tags as MRI Contrast Agents ChemBioChem 13

Article first published online: 13 NOV 2012 | DOI: 10.1002/cbic.201200448

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The ins and outs of water: Seventeen-residue lanthanide-binding tags (LBTs) have been used as a template for developing gadolinium-binding tags that exhibit enhanced contrast for MRI. The MRI-LBT sequence was further optimized as a coexpression tag on a model protein, ultimately affording a prototype peptide-based MRI agent.

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