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Karoline Nordsieck, Annelie Pichert, Dr. Sergey A. Samsonov, Dr. Lars Thomas, Dr. Christian Berger, Dr. M. Teresa Pisabarro, Prof. Dr. Daniel Huster and Prof. Dr. Annette G. Beck-Sickinger Residue 75 of Interleukin-8 is Crucial for its Interactions with Glycosaminoglycans ChemBioChem 13

Version of Record online: 15 OCT 2012 | DOI: 10.1002/cbic.201200467

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Protein–GAG interactions: Residue 75 of interleukin-8 (IL-8) plays a major role in the interactions between IL-8 and glycosaminoglycans (GAGs). Here, investigation of a selectively 15N-labeled E75K IL-8 variant by spectroscopic techniques and molecular docking has shown the importance of amino acids 34 to 36 for the interaction with GAGs for the first time.

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