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Dr. Saskia Wolf, Dr. Svenja Warnecke, Jörg Ehrit, Dr. Friedrich Freiberger, Prof. Dr. Rita Gerardy-Schahn and Prof. Dr. Chris Meier Chemical Synthesis and Enzymatic Testing of CMP-Sialic Acid Derivatives ChemBioChem 13

Version of Record online: 5 NOV 2012 | DOI: 10.1002/cbic.201200471

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Sialic acid modification: CycloSal-nucleotides were used to prepare monophosphate-linked sugar nucleotides, such as TMP-β-Gal and CMP–N-acetyl-neuraminic acids and four sialic acid derivatives with different modifications at their amino functions. The CMP–sialic acid derivatives were studied in a polymerisation catalysed by a bacterial polysialyltransferase.

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