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Jayne F. Koellhoffer, Dr. Gang Chen, Rohini G. Sandesara, Dr. Shridhar Bale, Prof. Dr. Erica Ollmann Saphire, Prof. Dr. Kartik Chandran, Prof. Dr. Sachdev S. Sidhu and Prof. Dr. Jonathan R. Lai Two Synthetic Antibodies that Recognize and Neutralize Distinct Proteolytic Forms of the Ebola Virus Envelope Glycoprotein ChemBioChem 13

Article first published online: 30 OCT 2012 | DOI: 10.1002/cbic.201200493

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A tale of two antibodies: Ebola virus (EBOV) causes severe hemorrhagic fever associated with high mortality rates. Here we report the identification of two synthetic antibody fragments that have orthogonal binding and neutralization profiles against two prefusion forms of the EBOV glycoprotein. These antibodies provide new tools for dissecting intermediates of viral membrane fusion and entry. (56 words)

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