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Karin S. Altmann, Dr. Antje Havemeyer, Prof. Dr. Eric Beitz and Prof. Dr. Bernd Clement Dimethylarginine-Dimethylaminohydrolase-2 (DDAH-2) Does Not Metabolize Methylarginines ChemBioChem 13

Article first published online: 4 NOV 2012 | DOI: 10.1002/cbic.201200499

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Physiological regulation of NO metabolism: Investigations into the methylarginine metabolism of DDAH-2 should yield evidence of isoform selectivity for DDAH-1 inhibitors. In contrast to DDAH-1, no metabolism of the postulated substrates L-NMMA or ADMA was observed for DDAH-2. Therefore, this reaction is not suitable to detect the influence of DDAH-1 inhibitors on DDAH-2 activity.

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