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Aiko Yahara, Dr. Ajaya Ram Shrestha, Dr. Tsuyoshi Yamamoto, Dr. Yoshiyuki Hari, Takashi Osawa, Masaki Yamaguchi, Dr. Masaru Nishida, Dr. Tetsuya Kodama and Prof. Dr. Satoshi Obika Amido-Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro Antisense Potency ChemBioChem 13

Version of Record online: 18 OCT 2012 | DOI: 10.1002/cbic.201200506

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Towards the next generation: New LNA analogues based on a cyclic amide structure, termed amido-bridged nucleic acids (AmNAs), have been synthesized. Oligonucleotides modified with these residues showed high nuclease resistance along with high binding affinities towards complementary strands.

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