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Dr. Kiran Matcha, Dr. Ashoka V. R. Madduri, Dr. Sayantani Roy, Dr. Slava Ziegler, Prof. Dr. Herbert Waldmann, Dr. Anna K. H. Hirsch and Prof. Dr. Adriaan J. Minnaard Total Synthesis of (−)-Doliculide, Structure–Activity Relationship Studies and Its Binding to F-Actin ChemBioChem 13

Article first published online: 5 NOV 2012 | DOI: 10.1002/cbic.201200512

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Actin' on cancers: An efficient catalytic, asymmetric synthesis of (−)-doliculide (shown in yellow) is reported. Its effect, and that of its analogues, was tested with two cancer cell lines. Its binding mode to F-actin was modeled and shown to be similar to that of jasplakinolide and chondramide C (gray).

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