E-mail a Wiley Online Library Link

Dr. Duncan E. Scott, Dr. Matthias T. Ehebauer, Dr. Tara Pukala, Dr. May Marsh, Prof. Sir Tom L. Blundell, Prof. Ashok R. Venkitaraman, Prof. Chris Abell and Dr. Marko Hyvönen Using a Fragment-Based Approach To Target Protein–Protein Interactions ChemBioChem 14

Version of Record online: 23 JAN 2013 | DOI: 10.1002/cbic.201200521

Thumbnail image of graphical abstract

Divide and conquer: Using a surrogate protein of Rad51, we created a fragment screening methodology to identify and biophysically validate fragments that bind in a small surface pocket involved in the interaction with the tumour suppressor BRCA2. A range of biophysical techniques including thermal shift, STD NMR spectroscopy, ITC and X-ray crystallography was employed.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field