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Dr. Duncan E. Scott, Dr. Matthias T. Ehebauer, Dr. Tara Pukala, Dr. May Marsh, Prof. Sir Tom L. Blundell, Prof. Ashok R. Venkitaraman, Prof. Chris Abell and Dr. Marko Hyvönen Using a Fragment-Based Approach To Target Protein–Protein Interactions ChemBioChem 14

Version of Record online: 23 JAN 2013 | DOI: 10.1002/cbic.201200521

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Divide and conquer: Using a surrogate protein of Rad51, we created a fragment screening methodology to identify and biophysically validate fragments that bind in a small surface pocket involved in the interaction with the tumour suppressor BRCA2. A range of biophysical techniques including thermal shift, STD NMR spectroscopy, ITC and X-ray crystallography was employed.

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