E-mail

E-mail a Wiley Online Library Link

Yazh Muthukumar, Myriam Roy, Aruna Raja, Prof. Dr. Richard E. Taylor and Dr. Florenz Sasse The Marine Polyketide Myriaporone 3/4 Stalls Translation by Targeting the Elongation Phase ChemBioChem 14

Article first published online: 9 JAN 2013 | DOI: 10.1002/cbic.201200522

Thumbnail image of graphical abstract

Myriaporone phosphorylates eEF2: The marine polyketide myriaporone has been shown to inhibit translation, but the mode of action was unknown. We now report that myriaporone 3/4 inhibits translation by inducing phosphorylation of elongation factor 2. Our results suggest that myriaporone 3/4 is a potential antiangiogenic drug lead.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH