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Jan Zimak, Dr. Ryan M. Schweller, Dr. Dzifa Y. Duose, Dr. Walter N. Hittelman and Dr. Michael R. Diehl Programming in Situ Immunofluorescence Intensities through Interchangeable Reactions of Dynamic DNA Complexes ChemBioChem 13

Version of Record online: 20 NOV 2012 | DOI: 10.1002/cbic.201200525

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Linear and branched DNA complexes have been designed to function as interchangeable building blocks that assemble, through DNA-strand-displacement reactions, into organized, fluorescence-reporting complexes. These complexes offer opportunities to tune the number of dyes coupled to individual antibodies so that marker levels can be amplified but also balanced within fixed cells.

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